Open Positions

1

Time Span

as soon as possible for 4 years

Application Deadline

31 Dec 2024

Financing

yes

Areas of study

Human Medicine, Veterinary Medicine, Molecular Biology, Human Biology, Biomedicine, Biochemistry

Description

Application deadline: 15/12/2024

The University Hospital Würzburg is seeking a motivated and talented PhD student (m/f/d) to join the
Emmy Noether Research Group led by Dr. Zoltan Nagy at the Institute of Experimental Biomedicine.
Be part of a dynamic research group and investigate fundamental mechanisms in hematology!
In this DFG-funded project, you will work at the forefront of megakaryocyte biology, leveraging state-of-the-art technologies, including single-cell transcriptomics, CRISPR gene editing, transgenic mouse models, and advanced imaging techniques.

We Offer
Access to cutting-edge laboratory facilities, including single-cell platforms, high-resolution
imaging systems, and automated immunoblotting technologies.
The opportunity to contribute to an exciting research project based on a recently discovered
signalling pathway crucial for megakaryocyte maturation.
Comprehensive training in molecular, cellular, and data analysis methods.
Personalized mentoring and a collaborative environment designed to support your professional
growth.

Your Tasks
Design and perform single-cell RNA sequencing experiments, applying advanced data analysis to
identify novel regulatory mechanisms.
Conduct in vivo studies in mouse models, focusing on experimental hematology techniques to
investigate and modulate platelet biogenesis.
Carry out in vitro cell culture experiments, utilizing stem cell differentiation protocols and
CRISPR-based gene editing to manipulate and study megakaryocyte function.
Perform innovative biochemical experiments, including advanced immunoblotting, to dissect key
signalling pathways involved in megakaryocyte development.
Present research findings at project meetings and conferences, and contribute to peer-reviewed
publications.

Your Profile
A Master’s degree in Biochemistry, Cell Biology, Molecular Biology, Hematology, or a related
field.
A strong foundation in molecular and cellular biology, with hands-on experience in cell culture and
techniques such as microscopy, flow cytometry, or Western blotting.
Interest in bioinformatics, including single-cell RNA-seq data analysis, and computational skills,
such as experience with data analysis tools (e.g., GraphPad) or programming languages like R,
would be an advantage.
Demonstrated scientific rigor, curiosity, and a willingness to learn and apply new methods.
Strong motivation and communication skills, with proficiency in written and spoken English
demonstrated through a language exam, thesis work, publications, or conference presentations.

To Apply
Please follow the link: https://karriere.ukw.de/en/p/wissenschaftundforschung/jobs/10814/phd-job-inwurzburg-megakaryocyte-biology-research
For further information, please do not hesitate to contact us at nagy_z@ukw.de.